Southampton caused an upset by beating Arsenal to secure their place in the FA Cup semi-finals.

Mikel Arteta has had nearly two weeks to reflect on his team's defeat to Manchester City in the Carabao Cup final, before focusing on the cup competition in which he has won his only major title to date.

With a third goal in mind, two early chances have already been created by Max Dowman and Gabriel Martinelli for Arsenal, but a shot by Martinelli was blocked by Taylor Harwood-Bellis.

However, the Championship leaders were not prepared to accept their fate as cannon fodder, with Léo Scienza accelerating to face Kepa Arrizabalaga directly before being successfully blocked by Cristhian Mosquera.

Arsenal were looking to increase the pressure, and Daniel Peretz had to make a save to keep out Martin Ødegaard's shot. Martin Ødegaard had another chance just a few minutes later, but his shot went over the crossbar, much to the disappointment of Arteta on the touchline.

And he must have felt even worse when Ross Stewart put Saints ahead with a precise finish after a quick counterattack, when James Bree's pass went over Ben White's head and set up the Scottish player to score against Kepa.

Dowman had the chance to equalise when his shot was blocked by Ryan Manning, but Arsenal's usual lack of defensive solidity almost cost them dearly once again.

Gabriel's lackadaisical pass to Tom Fellows on the opposite wing resulted in a shot that went over the crossbar. Sciencia then came close to scoring a second goal for Southampton in spectacular fashion when he dribbled the ball from the left wing into the box and shot with his right foot, but the ball hit the crossbar.

This unfortunate miss had serious consequences, as substitute Viktor Gyökeres — who had just helped Sweden qualify for the World Cup with the decisive goal against Poland — made an impact when he scored after Kai Havertz's reverse pass, following a pass from Gabriel.

From that moment on, Arsenal were expected to win, and Downes aimed to become the match hero with a beautiful left-footed shot, but Peretz made a successful save.

Martinelli then shot the ball wide from a corner, but the remarkable thing was that Southampton were the next to score, when Fellows made a strong run and passed to substitute Shea Charles, who calmly took a shot that beat Kepa, the ball hitting the post and going in.

After six minutes of tense added time, Tonda Eckert's team held on to win the match and secure a place in the semi-finals.

The German coach became the third Saints manager to win all four of their first FA Cup matches, after George Goss in 1925 and Alan Pardew in the 2009/10 season. They are now looking ahead to their visit to Wembley, while Arsenal have lost the opportunity to win another trophy after a disappointing fortnight for Arteta's team.